The National Security Advisor and U. S. Secretary of State under George W. Bush, Condi Rice is one of Bush's top advisors and accompanies him around the White House at briefings as well as to the FOX Network for negotiations with the Family Guy writers.
- A Ladder to Heaven (s06e12)
- Cartoon Wars Part I (s10e03; cameo)
- Cartoon Wars Part II (s10e04)
- Mystery of the Urinal Deuce (s10e09)